论文部分内容阅读
Objective: To study the best examination method of micrometastases in sentinel lymph node (SLN) of breast cancer and study the related factors with micrometastases. Methods: By step serial sectioning technique and immunohisto- chemistry, 121 SLNs and 44 tumors of 59 cases were examined. Results: Micrometastases was found in 17 SLNs (14%) of 14 (24%) cases. The more sections or examination methods, the more micrometastases were found. Micrometastases was related with the tumor size and the expression of c-erbB2, MMP-2 and VEGF. Conclusion: The best examination method is making sections at two levels with 100 μm interval and combination of HE staining and muc1 immunohistochemistry. We can get the excellent detection/cost by this method. Micrometastases is a bad prognostic factor.
Objective: To study the best examination method of micrometastases in sentinel lymph node (SLN) of breast cancer and study the related factors with micrometastases. Methods: By step serial sectioning technique and immunohisto- chemistry, 121 SLNs and 44 tumors of 59 cases were examined Results of Micrometastases was found in 17 SLNs (14%) of 14 (24%) cases. The more sections or examination methods, the more micrometastases were found. Micrometastases was related with the tumor size and the expression of c-erbB2, MMP -2 and VEGF. Conclusion: The best examination method is making sections at two levels with 100 μm interval and combination of HE staining and muc1 immunohistochemistry. We can get the excellent detection / cost by this method. Micrometastases is a bad prognostic factor.