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目的观察在常规治疗基础上加用低分子肝素治疗不稳定型心绞痛的临床疗效。方法入选94例不稳定型心绞痛患者,先予常规抗心绞痛药物如肠溶阿司匹林,硝酸盐制剂,受体阻滞剂、钙颉颃剂、ACEI类等治疗,效果不佳,在此基础上加用低分子肝素钠5000u,下腹壁皮下注射,每日2次,疗程为7d。结果用低分子肝素治疗后,本组患者心绞痛发作次数、持续时间及硝酸甘油含化用量均显著减少。对血液流变学指标均有显著的改善作用。结论在常规治疗基础上加用低分子肝素治疗不稳定型心绞痛,能显著缓解不稳定型心绞痛的临床症状,使用方便、安全,方法简单,用药期间无需实验室监测,故在不稳定型心绞痛的治疗中有广阔前景。
Objective To observe the clinical efficacy of low molecular weight heparin in the treatment of unstable angina pectoris based on routine treatment. Methods Ninety-four patients with unstable angina were enrolled in this study. First, conventional anti-anginal drugs such as enteric-coated aspirin, nitrates, receptor blockers, calcium antagonists and ACEI were given ineffectively. On this basis, Low molecular weight heparin 5000u, subcutaneous injection of the lower abdominal wall, 2 times daily, course of treatment for 7d. Results After treatment with low molecular weight heparin, the number of patients with angina pectoris, the duration and the amount of nitroglycerin were significantly reduced. Hemorheology indicators have a significant improvement. Conclusion The addition of low molecular weight heparin to unstable angina pectoris on the basis of routine treatment can significantly relieve the clinical symptoms of unstable angina pectoris, which is convenient and safe to use. The method is simple and requires no laboratory monitoring during the treatment. Therefore, in unstable angina pectoris Treatment has broad prospects.