论文部分内容阅读
目的:探讨血、尿β_2—MG的改变对痛风肾损害早期诊断的临床意义。方法:采用放射免疫方法测定20例健康对照者,40例痛风、10例高尿酸血症患者的血、尿β_2—MG,同时常规检测血清肌酐、尿素氮。结果:痛风性关节炎患者血清BUN、Cr尚未升高,血尿β_2—MG已显著升高(p<0.01和p<0.05)。结论:血、尿β_2—MG的测定是检测痛风、高尿酸血症早期肾损害的敏感指标。
Objective: To investigate the clinical significance of the changes of blood and urine β_2-MG in the early diagnosis of gout and kidney damage. Methods: The blood and urine β_2-MG of 20 healthy controls, 40 patients with gout and 10 patients with hyperuricemia were measured by radioimmunoassay. Serum creatinine and urea nitrogen were measured routinely. Results: Serum levels of BUN and Cr in gouty arthritis patients had not yet increased, while β_2-MG in hematuria was significantly increased (p <0.01 and p <0.05). Conclusion: The determination of blood and urine β_2-MG is a sensitive index to detect the early renal damage of gout and hyperuricemia.