论文部分内容阅读
目的:探讨来曲唑在高龄不孕患者体外受精-胚胎移植中的应用价值。方法:回顾性分析2008年3月～2010年8月接受IVF/ICSI-ET治疗的82例高龄不孕患者(年龄38～45岁),按促排方案分为来曲唑组(超短方案,n=37)与对照组(短方案,n=45)。比较组间的促性腺激素(Gn)使用剂量、Gn用药时间、绒毛膜促性腺激素(HCG)注射日子宫内膜(Em)厚度及血清促黄体生成素(LH)值、雌二醇(E2)值、获卵数、MII卵数、受精率、卵裂率、优质胚胎率、冷冻胚胎率、种植率和妊娠率。结果:来曲唑(LE)组与对照组Gn使用剂量、Gn用药时间、HCG日子宫内膜厚度、获卵数、MII卵数、受精率、妊娠率比较,差异无统计学意义(P>0.05)。来曲唑组HCG日血清激素LH值、E2值明显低于对照组,种植率明显高于对照组,差异有统计学意义(P<0.05)。结论:LE用于高龄不孕妇女超促排卵行IVF/ICSI-ET助孕,可以克服超生理剂量雌激素对内膜的毒性作用,对子宫内膜容受性的影响较小,胚胎种植率明显提高,有助于提高IVF/ICSI-ET妊娠率。
Objective: To investigate the value of letrozole in in vitro fertilization-embryo transfer in elderly patients with infertility. Methods: A retrospective analysis of 82 elderly infertile patients (aged 38-45 years) treated with IVF / ICSI-ET between March 2008 and August 2010 was divided into letrozole group , n = 37) and control group (short protocol, n = 45). The dose of gonadotropin (Gn), the duration of Gn treatment, the thickness of endometrium (Em) and the serum LH levels were measured on the day of injection of HCG. ) Value, number of oocytes retrieved, number of MII eggs, fertilization rate, cleavage rate, quality embryo rate, frozen embryo rate, implantation rate, and pregnancy rate. Results: There was no significant difference in the dosage of Gn, the duration of Gn administration, the thickness of endometrium on HCG day, the number of oocytes retrieved, the number of MII oocytes, fertilization rate and pregnancy rate between letrozole (LE) group and control group (P> 0.05). The LH and E2 values of serum hormone of HCG on letrozole group were significantly lower than those in control group, and the implantation rate was significantly higher than that of control group (P <0.05). Conclusions: LE can be used to overcome the toxic effect of hyperphysiological estrogen on endometrium with IVF / ICSI-ET, which has little effect on the endometrial receptivity. The implantation rate of embryo Significantly improved, help to improve IVF / ICSI-ET pregnancy rate.