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近年来,心血管病的药物治疗取得较大进展,而钙拮抗剂是继β阻滞剂之后的最重要进展。这类制剂作为一种降压药物,其应用范围正在扩大。本文仅就钙拮抗剂作为降压药物的有关方面,并以国内多用的硝苯啶(Nifedipine)为代表,结合临床作一讨论。一、钙拮抗剂的外周血管作用钙拮抗剂可扩张广泛的动脉和小动脉,减低周围血管阻力。原发性高血压的主要血液动力学改变,为小动脉平滑肌张力增加。钙离子内流激发血管平滑肌
In recent years, cardiovascular disease drug treatment made great progress, and calcium antagonists following the beta blocker after the most important progress. Such preparations as a kind of antihypertensive drugs, the scope of its application is expanding. This article only on calcium antagonists as antihypertensive drugs related aspects, and the domestic use of multi-purpose nifedipine (Nifedipine), combined with clinical discussion. A calcium antagonist peripheral vascular effects Calcium antagonists can expand a wide range of arteries and small arteries, reducing peripheral vascular resistance. The major hemodynamic changes in essential hypertension are the increase in arteriolar smooth muscle tone. Ca2 + influx triggers vascular smooth muscle