3-53 p53 Family Regulate MicroRNA Expression and Biogenesis in Cellular Response to IR

• 作 者: Zhang Hong Mao Aihong
• 机 构: 不详
• 出 处: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 发表日期: 2014年1期
• 关键词: FAMILY REGULATE MICRORNA
• 基金项目: Key Program of National Natural Science Foundation of China (U1432248), National Natural Science Foundationof China (11205219, 11305224)

p53 mainly exerts its function through transcriptional regulation of its targets. In response to various stresssignals, including the DNA damage response after IR, ATM phosphorylates p53 leads to its dissociation from MDM-2, an inhibitor of p53, and accum