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患者均因肺结核,大咯血用异烟肼、乙胺丁醇、利福平治疗后出现皮肤巩膜黄染,肝功异常,停抗痨药保肝治疗后肝功恢复正常,化验:痰菌(+),给吡嗪酰胺、异烟肼、对氨基水杨酸钠、链霉素治疗2个月痰菌阴转,随访未再复发。抗痨药对肝脏均有不同程度的损害,尤其是在复治病历中出现药物性肝炎,往往使抗痨治疗失败。以往人们认为吡嗪酰胺对肝的毒性较大,故很少采用,现在应用吡嗪酰胺证明不仅能大量杀死代谢活跃的结核菌,而且也可杀灭细胞内处于酸性环境
Patients were due to pulmonary tuberculosis, hemoptysis with isoniazid, ethambutol, rifampicin after treatment of skin scleral yellow dye, abnormal liver function, stopping anti-drug liver protection after liver function returned to normal, test: sputum bacteria +), To pyrazinamide, isoniazid, sodium sulfosalate, streptomycin treatment of sputum negative for 2 months, follow-up no recurrence. Anti-tuberculosis drugs have different degrees of damage to the liver, especially in the resumption of medical drug-induced hepatitis, often anti-tuberculosis treatment failed. In the past people think pyrazinamide greater toxicity to the liver, it is rarely used, and now pyrazinamide proved not only to kill a large number of metabolically active Mycobacterium tuberculosis, but also kill cells in an acidic environment