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目的 开展有效化疗研究以控制吴江地区美洲钩虫病的流行。方法 通过对美洲钩虫感染性的流行病学调查和比较不同化疗方案 ,选择和推广应用有效化疗方法。结果 结果表明美洲钩虫感染占 84 39% ,混合感染占8 89% ,美洲钩虫感染者的平均虫负荷为 2 82条 ,家庭聚集性K值为 0 5 6 ,G值为 32 5 44。在噻嘧啶、甲苯咪唑、阿苯达唑与甲苯咪唑伍用A组 ( 3片 )、甲苯咪唑与阿苯达唑联用B组 ( 6片 )、驱虫康Ⅰ组、驱虫康Ⅱ组的阴转率分别为82 93%、95 74%、91 6 0 %、95 74%、79 41%和 88 71%。实验村的感染率下降 91 13% ,对照村的感染率下降 13 37% ,有显著性差异。此外 ,防治试点的美洲钩虫感染率降至 3 17%。结论 采用连续选择性化疗方法控制美洲钩虫可取得较为满意的近期和远期效果。值得在美洲钩虫流行区推广、应用。
Objective To carry out effective chemotherapy to control the prevalence of American hookworm in Wujiang area. Methods By epidemiological survey of hookworm infection and compare different chemotherapy regimens, select and promote the use of effective chemotherapy. The results showed that the infection rate of hookworm was 84 39%, that of mixed infection was 89 89%, that of hookworm infection was 2 82, family aggregation value was 566, and G value was 32 5 44. Group A (3 tablets) was treated with pyrantel, mebendazole, albendazole and mebendazole in combination with mebendazole, group B (6 tablets) The negative conversion rates were 82 93%, 95 74%, 91 6 0%, 95 74%, 79 41% and 88 71%, respectively. The infection rate in experimental villages dropped by 91.13% while the infection rate in control villages dropped by 13.37%, showing significant differences. In addition, the control rate of hookworm infection in the pilot program dropped to 317%. CONCLUSIONS: Continuous and selective chemotherapies can be used to control the hookworm in the near future and long-term. Worth in the Americas hookworm epidemic promotion, application.