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越来越多的临床和实验证据证明,内分泌和代谢因素可能在动脉粥样硬化的病因学上具有重要意义。Phillips研究了性激素在动脉粥样硬化发病机理中的意义。传统的看法是,对动脉粥样硬化的发生,雌激素起保护作用,而雄激素起促进作用,这基本上是以下列流行病学资料为根据的,即妇女在生殖年龄时,冠状动脉血栓形成的危险性减少,在经绝期后危险性增加。然而,日服避孕药可增高缺血性心脏病的危险性这一事实,与上述见解栩反。Phillips证明,心肌梗死完全恢复并重新开始正常活动的较年轻的中年男子,其空腹血浆17β-雌二醇和雌酮水平明显高于同年龄组非动脉粥样硬化者。虽然这两组的血浆睾酮和二氢睾酮水平无明显差异,但动脉粥样硬化组的雌
A growing body of clinical and experimental evidence demonstrates that endocrine and metabolic factors may have important aetiological implications for atherosclerosis. Phillips studied the significance of sex hormones in the pathogenesis of atherosclerosis. The traditional view is that the occurrence of atherosclerosis, estrogen play a protective role, androgen play a catalytic role, which is basically based on the following epidemiological data that women at reproductive age, coronary artery thrombosis The risk of formation is reduced and the risk increases after the maturity. However, the fact that daily oral contraceptives increase the risk of ischemic heart disease is counterproductive. Phillips showed that younger middle-aged men with complete recovery of myocardial infarction and resuming normal activity had significantly higher fasting plasma 17β-estradiol and estrone levels than non-atherosclerotic individuals of the same age group. Although plasma testosterone and dihydrotestosterone levels were not significantly different between the two groups, the atherosclerosis group’s female