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前文报导了3,6-二[二甲氨基]-二苯并碘因甲酸盐的降压作用及其降压机制。最近又进一步对其中10种同类化合物进行了实验观察。药物均系兰州大学化学系黄文魁合成。所用药物列于表1。初筛后,对其中数种作了进一步的比较: 一、毒性为了在等毒性剂量的基础上比较其降压作用,先测定其毒性。用小白鼠252只,体重18—22克,分为七组,每组36只,每一种药物用36只小白鼠测定其LD_(50),腹腔注射药物水溶液,观察3天,计
The foregoing reports on the antihypertensive effect of 3,6-bis [dimethylamino] -dibenzyl formate and its antihypertensive mechanism. Recently, further experiments on 10 of these compounds have been conducted. Drugs are Department of Chemistry, Lanzhou University, Lanzhou synthesized. The drugs used are listed in Table 1. After screening, several further comparisons were made among them: 1. Toxicity To compare its antihypertensive effect on the basis of iso-toxic dose, the toxicity was determined first. 252 mice, weight 18-22 grams, divided into seven groups, each group of 36, each of the 36 mice were measured LD_ (50), intraperitoneal injection of drug solution, observed for 3 days, total