In-vitro cytotoxic activity of β-Sitosterol triacontenate isolated from Capparis decidua (Forsk.) Ed

• 作 者: Permender Rathee Dharmender Rathee Deepti Rathee Sushila Rathee
• 机 构: Department of Quality Assurance & Natural Products, PDM College of Pharmacy, Bahadurgarh, India“,”De
• 出 处: 亚太热带医药杂志（英文版）
• 发表日期: 2012年3期
• 关键词: Kair Capparis decidua Capparidaceae β-Sitosterol triacontenate Anticancer activi

Objective:To study the isolation and characterization of the constituent responsible for the cytotoxic activity of the ethanolic extract of stem ofCapparis decidua (C. decidua).Methods:The preliminary cytotoxic effect of isolated compound (β-Sitosterol triacontenate) was investigated byMTT assay onA549 solid tumor cells.Results:IC50 value of the β-Sitosterol triacontenate was found to be 1 μM. The cytotoxic activity increased in a dose dependent manner in case of β-Sitosterol triacontenate.Conclusions: The data therefore provide direct evidence for the role of β-Sitosterol triacontenate as a potent antimetastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant cells.