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目的观察奥美拉唑合用曲美布汀治疗反流性食管炎的疗效。方法将103例反流性食管炎患者随机分为2组:奥美拉唑合用曲美布汀组(治疗组)51例,奥美拉唑组(对照组)52例。治疗组采用奥美拉唑肠溶片20 mg/次,2次/d,每天早晚空腹服用,曲美布汀胶囊200 mg/次,3次/d,餐前0.5 h服用,共4周;对照组采用奥美拉唑肠溶片20mg/次,2次/d,每天早晚空腹服用,共4周,完成4周疗程后观察有效率。结果两组的有效率分别为92.2%、59.6%,差异有统计学意义(P<0.01)。结论奥美拉唑合用曲美布汀治疗反流性食管炎效果较好。
Objective To observe the efficacy of omeprazole combined with trimebutine in the treatment of reflux esophagitis. Methods 103 patients with reflux esophagitis were randomly divided into two groups: 51 cases omeprazole combined trimebutine group (treatment group), 52 cases omeprazole group (control group). The treatment group was omeprazole enteric-coated tablets 20 mg / time, 2 times / d, fasting day and night daily, trimebutine capsules 200 mg / time, 3 times / d, 0.5 h before meals for 4 weeks; The control group was omeprazole enteric-coated tablets 20mg / time, 2 times / d, taken fasting every day morning and evening, a total of 4 weeks, complete 4 weeks after treatment, observe the efficiency. Results The effective rates of the two groups were 92.2% and 59.6% respectively, the difference was statistically significant (P <0.01). Conclusion Omeprazole combined with trimebutine treatment of reflux esophagitis better.