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多发性骨髓瘤病人对VAD(长春新碱、阿霉素、地塞米松)的抗药性,与多药抗药性(MDR)表达有关.MDR-1基因产物是一种分子量为170KD的糖蛋白(PgP),在肿瘤细胞膜上呈过份表达.PgP起着一种能量依赖性流出泵的作用,它能降低细胞内药物浓度.MDR-1基因转染给对药物敏感的细胞.使之也呈现抗药性.难治性骨髓瘤病人中,PgP阳性者占很高比率,PgP过份表达的程度与抗药性程度相关.环孢霉素是几种能够阻断PgP功能(可能
Multiple myeloma patients with VAD (vincristine, doxorubicin, dexamethasone) resistance, and multidrug resistance (MDR) expression.MDR-1 gene product is a molecular weight of 170KD glycoprotein ( PgP) is overexpressed on the tumor cell membrane.PgP acts as an energy-dependent efflux pump that reduces the intracellular drug concentration.MDR-1 gene is transfected into drug-sensitive cells as well Drug resistance In patients with refractory myeloma, PgP-positive patients account for a high rate of PgP overexpression associated with the extent of drug resistance Cyclosporine is several that block PgP function