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本文旨在确定延长5’-单磷酸阿糖腺苷(ARA-AMP)和淋巴母细胞干扰素用药期是否会对HBV复制过程有长期的抑制作用.对象为1982年至1983年作者所在医院的内科患者共45例.均为HBsAg和HBeAg持续阳性6个月以上,血清中HBV DNA持续存在,SGOT升高,经组织学检查证实的慢性肝病患者.其中60%为同性恋,10例在12～30个月前接受过抗病毒治疗或短程皮质激素治疗.患者随机分为3组:组Ⅰ16例干扰素治疗12周;组Ⅱ15例ARA-AMP治疗4周;组Ⅲ14例ARA-AMP治疗7～8周.治疗分两个阶段:初始期(五天)
This article aims to determine whether extending the duration of ARA-AMP and lymphoblastoid interferon use will have a long-term effect on the HBV replication process from 1982 to 1983 in the author’s hospital There were 45 cases of medical patients, all of whom had persistent positive HBsAg and HBeAg more than 6 months, serum HBV DNA persisted and SGOT increased, histologically confirmed patients with chronic liver disease, of which 60% were homosexual, 10 were in 12 ~ 30 months before receiving antiretroviral therapy or short-course corticosteroids. The patients were randomly divided into three groups: group I16 interferon for 12 weeks; group II 15 ARA-AMP for 4 weeks; group III 14 ARA-AMP for 7 ~ 8 weeks.The treatment is divided into two stages: the initial period (five days)