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本课题对近年来治疗细菌性感染的重要选用药物氟喹诺酮类抗菌药的6个品种共12个制剂进行了系统的药效学、临床药理学研究和临床评价。研究内容简述如下。 (一)氟喹诺酮类临床药物动力学研究氟喹诺酮类在健康志愿者中的药物动力学研究结果显示单剂空腹口服环丙沙星、氧氟沙星、依诺沙星、诺氟沙星、洛美沙星、、氟罗沙星后
This topic systematically studied the pharmacodynamics, clinical pharmacology and clinical evaluation of 12 preparations of six kinds of fluoroquinolone antibacterials, which are important selection drugs for the treatment of bacterial infections in recent years. The research is summarized as follows. (A) fluoroquinolone clinical pharmacokinetic studies Fluoroquinolones in healthy volunteers in the pharmacokinetic studies showed that single oral fasting ciprofloxacin, ofloxacin, enoxacin, norfloxacin, Lomefloxacin, after fleroxacin