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目的探讨全血超敏C-反应蛋白在儿童呼吸道感染中的应用价值。方法选择2015年1月-2015年6月宝鸡市中心医院收治的患儿230例,按照病因分为细菌性肺炎组74例,病毒性肺炎组62例,化脓性扁桃体炎组51例,哮喘组43例。同时选择健康体检儿童100例作为对照组。采集静脉血,使用ASTEP分析仪检测全血超敏C-反应蛋白水平,2组比较采用t检验,多组间比较采用方差分析。结果病毒性肺炎组、哮喘组的hs-CRP结果与对照组比较差异无统计学意义(P>0.05)。细菌性肺炎组、化脓性扁桃体炎组的hs-CRP结果与对照组比较明显增高,差异有统计学意义(P<0.01)。4种呼吸道疾病全血hs-CRP差异有统计学意义(P<0.05)。细菌性肺炎组和化脓性扁桃体炎组在治疗后hs-CRP较治疗前显著下降,差异有统计学意义(P<0.01)。而病毒性肺炎组和哮喘组hs-CRP比较差异无统计学意义(P>0.05)。结论超敏C-反应蛋白对儿童呼吸道感染的诊断及鉴别诊断具有重要临床意义,对儿童呼吸道感染的治疗方案选择和疗效评估有一定的临床应用价值。
Objective To investigate the value of whole blood hypersensitive C-reactive protein in children with respiratory tract infection. Methods From January 2015 to June 2015, 230 cases of children admitted to Baoji Central Hospital were divided into four groups: bacterial pneumonia group (74 cases), viral pneumonia group (62 cases), purulent tonsillitis group (51 cases), asthma group 43 cases. At the same time, 100 healthy children were selected as the control group. Venous blood was collected and the level of Hypersensitivity C-reactive protein in whole blood was measured by ASTEP analyzer. T test was used in the two groups, and ANOVA was used to compare the multiple groups. Results The results of hs-CRP in viral pneumonia group and asthma group were not significantly different from those in control group (P> 0.05). Bacterial pneumonia group, suppurative tonsillitis group hs-CRP results compared with the control group was significantly higher, the difference was statistically significant (P <0.01). The difference of hs-CRP in the four kinds of respiratory diseases was statistically significant (P <0.05). Bacterial pneumonia group and suppurative tonsillitis group hs-CRP decreased significantly after treatment than before treatment, the difference was statistically significant (P <0.01). There was no significant difference in hs-CRP between viral pneumonia group and asthma group (P> 0.05). Conclusions Hypersensitive C-reactive protein has important clinical significance in the diagnosis and differential diagnosis of children’s respiratory tract infections. It has certain clinical value in the treatment options and efficacy evaluation of children’s respiratory infections.