论文部分内容阅读
目的:探讨合并真菌感染肺结核的临床表现及其耐药性。方法:回顾性分析2010年3月~2013年3月于我院治疗的133例肺结核并发真菌感染患者的临床资料。结果:133例并发真菌感染肺结核患者以合并下呼吸道细菌感染,低蛋白血症,糖尿病,广谱抗生素或糖皮质激素长时间使用患者为主。病原菌检测结果显示大部分为白色假丝酵母菌(72.18%)。两性霉素B、5-氟胞嘧啶和伊曲康唑是对真菌耐药率最低的常用抗真菌药物。经抗真菌治疗后,116例痰菌检测由阳性转变为阴性,11例没有变化,6例死亡,死亡率4.51%。结论:肺结核并发真菌感染患者有增加的趋势,对其病变特点及耐药情况,临床应予以重视。
Objective: To investigate the clinical manifestations and drug resistance of pulmonary tuberculosis complicated with fungal infection. Methods: The clinical data of 133 patients with fungal pulmonary tuberculosis complicated with fungal infection treated in our hospital from March 2010 to March 2013 were retrospectively analyzed. Results: Of the 133 patients with fungal infection with pulmonary tuberculosis, patients with lower respiratory tract bacterial infection, hypoalbuminemia, diabetes, broad-spectrum antibiotics or glucocorticoid were used for a long time. Pathogen test results showed that the majority of Candida albicans (72.18%). Amphotericin B, 5-fluorocytosine and itraconazole are commonly used antifungal agents with the lowest rates of fungal resistance. After antifungal treatment, 116 cases of sputum from positive to negative, 11 cases did not change, 6 died, the mortality rate was 4.51%. Conclusion: There is an increasing trend in patients with pulmonary tuberculosis complicated with fungal infection, and its characteristics and drug resistance should be emphasized clinically.