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心肌雷诺定受体2是一种心肌细胞钙释放通道,对心肌Ca2+循环起着至关重要的作用。该受体的功能受心肌钙调控蛋白FKBP12.6、SERCA2a和CASQ2等的影响,而此类蛋白的表达又与内皮素-NADPH氧化酶(ET-NOX)途径有关。ET-NOX途径和心肌钙调控蛋白的异常均会导致心律失常和心衰。因此,ET-NOX途径中各成员以及心肌钙调控蛋白有可能成为治疗心律失常和心衰的新靶标。综述了心肌钙调控蛋白和ET-NOX途径在正常心肌兴奋收缩耦联过程及病理过程中的作用,并介绍了相关的在研抗心律失常药物。
Cardiac Reynold’s Receptor 2 is a cardiomyocyte calcium-releasing pathway that plays a crucial role in myocardial Ca 2+ cycling. The function of this receptor is affected by cardiac calcium regulatory proteins FKBP12.6, SERCA2a and CASQ2, etc., and the expression of these proteins is related to the ET-NOX pathway. Abnormalities in ET-NOX pathway and cardiac calcium control proteins can lead to arrhythmias and heart failure. Therefore, each member of the ET-NOX pathway as well as the cardiac calcium regulatory proteins may be new targets for the treatment of arrhythmias and heart failure. The roles of cardiac calcium-regulated protein and ET-NOX pathway in the excitation and contraction coupling of normal myocardium and their pathological processes were reviewed. Relevant in-process antiarrhythmic drugs were introduced.