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采用ＥＬＩＳＡ双抗体夹心法检测１１０例免疫性疾病患者血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）水平，与正常人比较，系统性红斑狼疮（ＳＬＥ）、特发性血小板减少紫癜（ＩＴＰ）、自身免疫性溶血性贫血（ＨＡ）、Ｅｖａｎｓ综合征等病患者血清ｓＩＬ－２Ｒ均有不同程度增高，分别为１３４１．７±５６５．７，１１４３．１±３４７．８，１３３０．９±３５７．０和１４４１．３±９７．２Ｕ／ｍｌ，且与正常对照（４１９．１±２４３．７）间差异存在显著性。ＩＴＰ病人ｓＩＬ－２Ｒ与末梢血小板数量呈明显负相关；ＳＬＥ活动期和非活动期患者ｓＩＬ－２Ｒ差别显著（Ｐ＜０．００１）。认为ｓＩＬ－２Ｒ可作为免疫性疾病诊断、病情监测及反映机体免疫功能状况的一个有用指标。
Serum soluble interleukin-2 receptor (sIL-2R) levels were measured in 110 patients with autoimmune diseases by ELISA double antibody sandwich method. Compared with normal subjects, systemic lupus erythematosus (SLE), idiopathic thrombocytopenic purpura (ITP ), Serum autoimmune hemolytic anemia (HA), Evans syndrome and other patients with serum sIL-2R increased to varying degrees, respectively, 1341.7 ± 565.7,1143.1 ± 347.8,1330.9 ± 357.0 and 1441.3 ± 97.2U / ml respectively, and there was significant difference with the normal control (419.1 ± 243.7). The level of sIL-2R in ITP patients was negatively correlated with the number of peripheral platelets. The difference of sIL-2R between active and inactive SLE patients was significant (P <0.001). That sIL-2R can be used as a diagnosis of immune disease, disease surveillance and reflect the status of the body’s immune function is a useful indicator.