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目的分析岭南地区常住人口的25羟维生素D3与骨密度、肌酐、尿酸、空腹血糖、血脂等的关系,评价岭南地区人群骨质疏松风险。方法于2016年采集以上人群数据并根据性别、年龄、骨密度值、25羟维生素D3水平进行分组评价。结果4 450例岭南地区常住人口的25羟维生素D3平均水平高于北方地区,男性29.70±9.43ng/m L,女性25.00±7.72ng/m L,均处于正常范围。肌酐(r=0.245,P<0.01)、年龄(r=0.214,P<0.01)与其正相关程度较强;随着年龄的增长,25羟维生素D3水平逐渐增高,其中男性偏高于女性,而女性在60岁以后出现下降趋势。而25(OH)D3与体重、血压、血脂、尿酸、空腹血糖和骨密度等相关性不强。结论 25(OH)D3可能与地域纬度、性别、年龄、肌酐和雌激素水平有相关性,但其机理有待研究。25(OH)D3与骨密度值相关性不强,可能是不影响骨质疏松的主要因素。
Objective To analyze the relationship between 25-hydroxyvitamin D3 and bone mineral density (BMD), creatinine, uric acid, fasting blood glucose, blood lipids in resident population in Lingnan area and evaluate the risk of osteoporosis in Lingnan area. Methods The above population data were collected in 2016 and evaluated by grouping according to gender, age, bone mineral density, and 25-hydroxyvitamin D3 levels. Results The average level of 25 hydroxyvitamin D3 in 4 450 permanent residents in Lingnan area was higher than that in the north, with 29.70 ± 9.43 ng / m L for males and 25.00 ± 7.72 ng / m L for females, all within the normal range. Creatinine (r = 0.245, P <0.01), and age (r = 0.214, P <0.01). There was a positive correlation between 25 creatinine and age (r = 0.214, P <0.01) Women show a downward trend after the age of 60. The 25 (OH) D3 and weight, blood pressure, blood lipids, uric acid, fasting blood glucose and bone mineral density and other related not strong. Conclusion 25 (OH) D3 may be related to latitude, sex, age, creatinine and estrogen level, but its mechanism needs to be studied. 25 (OH) D3 and bone mineral density value is not strong, may not affect the main factors of osteoporosis.