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恶性非何杰金氏淋巴瘤可原发于淋巴结外的部位,包括胃肠道、骨、甲状腺、皮肤、眼眶、睾丸、肺及乳房等。而原发性脑非何杰金氏淋巴瘤(PNHL-B)则较为少见。1929年Bailey 首先描述2例原发于脑网状内皮系统肉瘤患者的临床征象,作者称之为软脑膜血管周围肉瘤。1938年 Yuile 报告了第3例相似患者,并声称此类肉瘤起源于小神经胶质细胞,故又名小神经胶质细胞瘤。此后曾有不少命名,如多形性网状细胞肉瘤、网状内皮细胞肉瘤及网状细胞肉瘤等,而以后者最为常用。本文就 PNHL-B 有关问题作一综述。
Malignant non-Hodgkin’s lymphoma can be primary in the lymph nodes, including the gastrointestinal tract, bone, thyroid, skin, eyes, testis, lungs and breasts. The primary brain non-Hodgkin’s lymphoma (PNHL-B) is more rare. In 1929 Bailey first described two cases of clinical signs of primary reticuloendotheliosis in patients with sarcoma, the authors called periventricular sarcoma. In 1938 Yuile reported a third case of similar patients, and claimed that such sarcoma originated in microglial cells, it is also known as microglioma. Since then there have been many names, such as pleomorphic reticulocyte sarcoma, reticuloendothelial sarcoma and reticular cell sarcoma, etc., while the latter most commonly used. This article reviews the issues related to PNHL-B.