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目的 了解急性脑血管病患者血清白介素-8(IL-8)改变的意义。方法 采用ELISA方法测定了74例急性脑血管病患者(40例脑出血,34例脑梗死)和30例健康对照者的血清IL-8含量。结果 急性脑血管病患者血清IL-8水平(10728±3816ng/L),明显高于正常对照组(5135±1329ng/L)。急性脑出血和急性脑梗死组患者血清IL-8水平(11332±3955ng/L和9773±4388ng/L)均明显高于正常对照组,而它们之间则无明显差别。结论 急性脑血管病患者急性期血清IL-8水平明显升高,提示IL-8可能参与了急性脑血管病的发病过程。
Objective To understand the significance of serum interleukin-8 (IL-8) in patients with acute cerebrovascular disease. Methods Serum IL-8 levels were measured in 74 patients with acute cerebrovascular disease (40 cerebral hemorrhage, 34 cerebral infarction) and 30 healthy controls by ELISA. Results Serum levels of IL-8 in patients with acute cerebrovascular disease (10728 ± 3816 ng / L) were significantly higher than those in the normal controls (5135 ± 1329 ng / L). Serum levels of IL-8 (11332 ± 3955ng / L and 9773 ± 4388ng / L) in patients with acute cerebral hemorrhage and acute cerebral infarction were significantly higher than those in the normal control group, but there was no significant difference between them. Conclusion Serum levels of IL-8 in patients with acute cerebrovascular disease are significantly increased, suggesting that IL-8 may be involved in the pathogenesis of acute cerebrovascular disease.