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目的:分析头孢曲松钠用药方法及不良反应病例,为临床合理用药提供参考。方法:收集本院近4年收治的头孢曲松钠致药品不良反应个案病例报告共216例进行回顾性分析,采用Excel程序软件统计头孢曲松钠的用药情况以及不良反应发生情况。结果:头孢曲松钠的用药剂量以2.0 g居多,占比92/216(42.59%),用药途径以静脉滴注居多,占比187/216(86.57%);另外,头孢曲松钠的不良反应涉及多器官系统,以皮肤黏膜损害最多,占比128/216(59.26%),其次为全身性损害,占比57/216(26.39%)。并且统计得知头孢曲松钠大部分不良反应发生在给药过程中的60 min以内,占比193/216(89.35%)。结论:头孢曲松钠所致不良反应涉及多个系统,多发于用药1 h内,临床应采取适当措施以减少不良反应的发生,确保临床的安全用药。
OBJECTIVE: To analyze ceftriaxone sodium administration methods and adverse reactions, and to provide a reference for clinical rational drug use. Methods: A total of 216 cases of ceftriaxone induced adverse drug reactions were collected from our hospital in the past 4 years for retrospective analysis. The application of ceftriaxone sodium and the incidence of adverse reactions were analyzed by Excel software. Results: The dose of ceftriaxone sodium was mostly 2.0 g, accounting for 92/216% (42.59%). Most of the doses of ceftriaxone were administered intravenously, accounting for 187/216 (86.57%). In addition, ceftriaxone sodium The response involved multiple organ systems, with the highest mucosal damage, accounting for 128/216 (59.26%) followed by generalized lesions accounting for 57/216 (26.39%). Statistics and statistics found that most of the adverse reactions of ceftriaxone occurred within 60 minutes during the administration, accounting for 193/216 (89.35%). CONCLUSIONS: The adverse reactions caused by ceftriaxone involve multiple systems and occur frequently within 1 hour of medication. Appropriate measures should be taken in clinical practice to reduce the incidence of adverse reactions and ensure clinical safe medication.