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栓剂是一种经典的腔道给药剂型,能避免肝脏首过效应是其独特优点,但栓剂易变形、氧化、潮解、变质等问题一直没有得到根本解决。针对栓剂存在的问题,我们在研究实践的基础上集栓形、泡腾剂以及栓剂各自的优势和特色,提出并设计了泡腾胶囊栓。本文讨论了栓剂的研究现状及存在的问题,并着重阐述了泡腾胶囊栓的研究设计思路及其优势特点。
Suppository is a classical cavity administration dosage form. It is its unique advantage to avoid the first-pass effect of the liver. However, the problems of easy deformation, oxidation, deliquescence and deterioration of suppository have not been fundamentally solved. In view of the existing problems of suppositories, we put forward the design and design of effervescent capsules suppository based on the research practice of the advantages and characteristics of the plug, effervescent and suppository. This article discusses the research status and existing problems of suppositories, and emphatically expounds the research design ideas and advantages and advantages of effervescent capsule suppositories.