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我科从1995年1月起,采用外照射合并羟基喜树碱(HCPT)膀胱内灌注治疗晚期膀胱癌出血患者15例,取得了较好的疗效,现报告如下:1 材料与方法1.1 资料 15例患者中,男13例、女2例,年龄60～83岁.均经病理证实,14例为移行上皮细胞癌,1例为粘液样腺癌.12例为手术后残留或复发,经尿道膀胱镜肿瘤切除(TURBT)3例.所有病例都有肉眼血尿症状,最长2年,最短2周.临床分期按Jew-ett-Marshall分期,B期2例,C期8例,D期5例.1.2 方法 15例均采用外照射同时联合羟基喜树碱膀胱内灌注.外照射采用国产ZJ-108mV直线加速器,设一前二侧野,在模拟机下膀胱造影定位,前野包括全膀胱,二侧野后界避开直肠,剂量比为2:1:1总剂量40～60GY/20～30times/4～6w.羟
Our department from January 1995 onwards, the use of external irradiation with hydroxycamptothecin (HCPT) intravesical instillation of advanced bladder cancer hemorrhage in 15 patients, and achieved good results, are as follows: 1 Materials and methods 1.1 Materials 15 Among the patients, 13 were male and 2 were female, ranging in age from 60 to 83. Pathologically, 14 were transitional cell carcinoma and 1 was myxoid adenocarcinoma. Twelve cases were residual or recurrent after transurethral resection Cystoscope resection (TURBT) in 3. All cases have gross hematuria symptoms, up to 2 years, the shortest 2 weeks. Staging according to Jew-ett-Marshall staging, B in 2 cases, C in 8 cases, D 5 Cases .1.2 Methods 15 cases were treated with external irradiation combined with hydroxycamptothecin intravesical instillation.External irradiation using domestic ZJ-108mV linear accelerator, set a first two fields, in the simulator under the cystography, the anterior field, including the entire bladder, On both sides of the back of the field to avoid the rectum, the dose ratio of 2: 1: 1 total dose of 40 ~ 60GY / 20 ~ 30times / 4 ~ 6w.