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本文作者首次报导1例婴儿于围产期获得ECHO病毒21型感染,引起暴发性肝坏死。病例男婴,第3胎,剖腹产,体重2580g。母亲分娩时无任何疾病,而其父患胃肠道病。出生后1、5分钟Apgar计分为9分。出生后尽管出现精神不振,但吸奶良好。生后第4天出现黄疸,总胆红质132mg/L,直接胆红质30mg/L,第5天患儿极度软弱,体温过低,皮肤出现瘀点,诊为败血症。白细胞计数21×10~9/L(分叶核白细胞0.1,带状核细胞0.37,晚幼粒细胞0.03,中幼粒细胞0.04,淋巴细胞0.4,单核细胞0.06),血小板计数40×10~9/L,凝血酶原时间38.4s,部分凝血活酶时间>100s,纤维蛋白原0.5g/L,因子16%。因凝血功能障碍未做腰椎
The authors first reported that 1 infant was infected with ECHO virus type 21 during perinatal period, causing fulminant hepatic necrosis. Case baby boy, third child, caesarean section, weight 2580g. Mother without any disease during childbirth, and his father suffering from gastrointestinal disease. Apgar scored 9 points after birth 1,5 minutes. Despite the lack of energy after birth, but good milk. 4 days after birth jaundice, total bilirubin 132mg / L, direct bilirubin 30mg / L, the first 5 days of children with extreme weakness, hypothermia, skin petechia, diagnosed as sepsis. White blood cell count was 21 × 10 ~ 9 / L (apomixerum 0.1, nucleated cells 0.37, late promyelocytes 0.03, meiocytes 0.04, lymphocytes 0.4, monocytes 0.06), platelet count 40 × 10 ~ 9 / L, prothrombin time 38.4s, partial thromboplastin time> 100s, fibrinogen 0.5g / L, factor 16%. Due to coagulopathy did not do lumbar