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目的观察短期应用缬沙坦对慢性充血性心力衰竭(CHF)合并慢房颤患者室性心律失常的影响。方法选择45例CHF合并慢房颤室性心律失常患者,均给予常规治疗,加用缬沙坦胶囊80 mg,每天1次,治疗8周。治疗前后分别行动态心电图检查,测量左室射血分数(LVEF),测定血清钾浓度。结果经8周缬沙坦治疗后室性早搏、室性心动过速发生率明显降低(P<0.01);缬沙坦治疗前后LEVF比较差异有统计学意义(P<0.05)。结论短期应用缬沙坦可能对CHF患者室性心律失常有效。
Objective To observe the effect of short-term valsartan on ventricular arrhythmias in patients with chronic congestive heart failure (CHF) and chronic atrial fibrillation. Methods Forty-five CHF patients with ventricular arrhythmia were enrolled in this study. All patients were given conventional therapy. Valsartan 80 mg was added once daily for 8 weeks. Before and after treatment, respectively, dynamic ECG, left ventricular ejection fraction (LVEF) measured serum potassium concentration. Results After 8 weeks of valsartan treatment, the incidence of ventricular premature beats and ventricular tachycardia was significantly decreased (P <0.01). The difference of LEVF before and after valsartan treatment was statistically significant (P <0.05). Conclusion Short-term valsartan may be effective for CHF in patients with ventricular arrhythmias.