论文部分内容阅读
随着广谱抗菌素、类固醇激素、免疫抑制剂、抗肿瘤药物的广泛应用,放射医学、器官移植、导管插管等不断开展,深部真菌病日益多见,针对这种情况,抗真菌药物也应运而不断发展,如多烯类抗真菌抗菌素品种逐渐增加,然对较常见的念珠菌病、隐球菌病等,或因效果欠佳,或因其毒性及副反应较多,亟需寻找一些更有效的抗真菌药物。近十余年来对这方面较有希望的非多烯类抗真菌药物,
With the widespread use of broad-spectrum antibiotics, steroid hormones, immunosuppressive agents and anti-tumor drugs, radiation medicine, organ transplantation, catheterization and catheterization are increasingly carried out, and deep mycoses are increasingly seen. Antifungal agents should also be used in this situation And the continuous development, such as polyene antifungal antibiotics varieties gradually increased, but for the more common candidiasis, cryptococcosis, etc., or due to poor performance, or because of its toxicity and side effects are more urgent need to find some more Effective antifungal drug. Nearly ten years more promising in this regard non-polyene antifungal drugs,