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目的观察长期氨氯地平治疗对肥厚心肌的逆转作用。方法用动态血压仪记录经过４周氨氯地平治疗高血压病人的降压效果，用Ｍ－型超声仪测量２０例有心室肥厚患者的左心肥厚的改善情况。结果３０例原发性高血压患者接受氨氯地平治疗，４周后，ＡＢＰＭ值平均下降１１．２±７／８．８±４．９ｍｍＨｇ（Ｐ＜０．００１），治疗前后血压节律和心率均无显著变化（Ｐ＞０．０５）。２０例高血压合并左室肥厚的患者接受氨氯地平治疗２４周，左室后壁厚度、室间隔厚度、左室心肌质量和左室质量指数较治疗前显著减低（Ｐ＜０．００１）。结论氨氯地平治疗能有效地控制血压的升高，对心肌肥厚有逆转作用
Objective To observe the reversal effect of long-term amlodipine treatment on hypertrophic myocardium. Methods The antihypertensive efficacy of amlodipine in patients with hypertension was recorded by ambulatory blood pressure meter. The improvement of left ventricular hypertrophy in 20 patients with ventricular hypertrophy was measured by M-mode sonography. Results Thirty patients with essential hypertension were treated with amlodipine. After four weeks, ABPM decreased by an average of 11.2 ± 7 / 8.8 ± 4.9mmHg (P <0.001). Blood pressure rhythm and heart rate No significant change (P> 0.05). Twenty patients with hypertension and left ventricular hypertrophy were treated with amlodipine for 24 weeks. The thickness of left ventricular posterior wall, ventricular septal thickness, left ventricular mass and left ventricular mass index were significantly lower than those before treatment (P <0.001). Conclusion Amlodipine can effectively control the blood pressure and reverse the myocardial hypertrophy