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在早产儿通过未闭的动脉导管,常有明显的左至右分流,这可使呼吸窘迫综合征患婴的心肺功能恶化,引起严重的充血性心力衰竭,且用毛地黄和利尿剂治疗常无效,以致需要手术结扎动脉导管。前列腺素能影响动脉导管平滑肌的张力,有人提出应用抑制前列腺素合成的药物治疗早产儿呼吸窘迫综合征,能使导管收缩,甚至完全关闭。消炎痛为强有力的前列腺素合成抑制剂,甚至在用药后24小时内就可使导管关闭。应用氯喹亦可达到同样的效果。
In preterm infants through the patent ductus arteriosus, there are often obvious left to right shunt, which can make respiratory and respiratory distress syndrome infants with deteriorating heart and lung function, causing severe congestive heart failure, and treatment with digitalis and diuretics often Invalid, resulting in the need for surgical ligation of the ductus arteriosus. Prostaglandins can affect the tension of the arterial ductal smooth muscle. It has been suggested that the use of drugs that inhibit prostaglandin synthesis in the treatment of respiratory distress syndrome in preterm infants causes contraction or even complete closure of the catheter. Indomethacin is a potent inhibitor of prostaglandin synthesis and can be used to close the catheter even within 24 hours of treatment. Application of chloroquine can achieve the same effect.