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获得性免疫缺陷综合征(AIDS)发生于健康人,临床特点有感染和恶性肿瘤,如Kaposi氏肉瘤。约40％患者于6个月内死亡,2年病死率为80％。AIDS患者细胞免疫受抑制,伴循环血中辅助T细胞(TH)减少和抑制性T细胞(TS)增多。应用免疫兴奋药、骨髓移植均无效。因免疫缺陷在成熟的TH,所以作者认为若通过输注HLA同型的淋巴细胞,也许能恢复其正常免疫功能。作者报道1例AIDS患者暂时性输注其姊妹的HLA和混合淋巴细胞培养同型的淋巴细胞。患者男性44岁(两性畴型)。素来健康。1982年6月患卡氏肺囊虫肺炎。鼻、舌有疱疹伴溃瘍,后自动愈合,但口腔持续患鹅口疮。血液淋巴细胞计数为1,105/μl,其中T细胞720/μl,TH/TS比值为0.44。自然杀伤(NK)细胞用Leu T染色测定增至42％。6个迟发型皮肤过敏反应接种部位仅1处呈局限性阳性(5×6mm)。全血对植物血凝素(PHA)的增殖性反应低,淋巴细胞对抗原刺激无明显增殖反应。
Acquired immunodeficiency syndrome (AIDS) occurs in healthy people and is clinically characterized by infections and malignancies such as Kaposi’s sarcoma. Approximately 40% of patients die within 6 months, with a 2-year case-fatality rate of 80%. AIDS patients with suppressed cellular immunity, with a decrease in circulating blood helper T cells (TH) and suppressor T cells (TS) increased. Application of immune stimulants, bone marrow transplantation were ineffective. Due to the immunodeficiency in mature TH, the authors believe that if the HLA isotype of lymphocytes by infusion, may be able to restore its normal immune function. The authors report that one patient with AIDS was transiently infused with his sister’s HLA and mixed lymphocytes to culture the same type of lymphocytes. The patient was 44 years old (amphoteric). Always healthy. June 1982 suffering from Pneumocystis carinii pneumonia. Nasal, tongue herpes associated with ulcers, after the automatic healing, but the mouth sustained thrush. The blood lymphocyte count was 1,105 / μl, with 720 cells / μl of T cells and a TH / TS ratio of 0.44. Natural killer (NK) cells were increased to 42% with Leu T staining. Only 6 sites of 6 delayed type hypersensitivity reactions were localized positive (5 × 6 mm). Whole blood lectin phytohemagglutinin (PHA) proliferative response is low, lymphocyte antigen stimulation no significant proliferative response.