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目的:观察耳后注射甲泼尼龙治疗糖尿病患者突发性聋的临床疗效。方法:选择糖尿病患者突发性聋85例,随机分为对照组44例和观察组41例。对照组采用全身激素治疗,观察组采用甲泼尼龙耳后乳突骨膜下注射治疗。比较两组临床疗效、听力改善情况、不良反应及血糖波动情况。结果:观察组总有效率85.4%,显著高于对照组的70.5%(P<0.05)。治疗后,两组纯音听阈均较治疗前显著改善(P<0.05);观察组纯音听阈显著低于对照组,听阈降低值显著高于对照组(P<0.05)。观察组不良反应发生率7.3%,显著低于对照组的13.6%(P<0.05);观察组血糖变化与甲泼尼龙代谢时间相一致。结论:耳后注射甲泼尼龙治疗糖尿病患者突发性聋疗效较好,安全性较高。
Objective: To observe the clinical effect of injection of methylprednisolone into sudden hearing loss in diabetic patients. Methods: Eighty-five patients with sudden deafness were randomly divided into control group (n = 44) and observation group (n = 41). The control group was treated with systemic hormones. The observation group was treated with subperiosteal injection of methylprednisolone. The clinical efficacy, hearing improvement, adverse reactions and blood glucose fluctuation were compared between the two groups. Results: The total effective rate in observation group was 85.4%, which was significantly higher than that in control group (70.5%, P <0.05). After treatment, pure tone thresholds were significantly improved in both groups (P <0.05). The pure tone threshold of the observation group was significantly lower than that of the control group, and the threshold value of hearing threshold was significantly higher than that of the control group (P <0.05). The adverse reaction rate in observation group was 7.3%, which was significantly lower than that in control group (13.6%, P <0.05). The change of blood glucose in observation group was consistent with that of methylprednisolone. Conclusion: The effect of injection of methylprednisolone into the treatment of sudden deafness in diabetic patients is better and the safety is higher.