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AIM:The purpose of this review is to describe the variousaspects of primary gastric lymphoma and the treatmentoptions currently available.METHODS:After a systematic search of Pubmed,Medscapeand MDconsult,we reviewed and retrieved literature regardinggastric lymphoma.RESULTS:Primary gastric lymphoma is rare however,theincidence of this malignancy is increasing.Chronic gastritissecondary to Helicobacter pylori (H pylori) infection has beenconsidered a major predisposing factor for MALT lymphoma.Immune histochemical marker studies and molecular biologyutilizing polymerase chain reaction have facilitated appropriatediagnosis and abolished the need for diagnostic surgicalresection.Advances in imaging techniques including MagneticResonance Imaging (MRI) and Endoscopic Ultrasonography(EUS) have helped evaluation of tumor extension and invasion.The clinical course and prognosis of this disease is dependenton histopathological sub-type and stage at the time ofdiagnosis.Controversy remains regarding the best treatmentfor early stages of this disease.Chemotherapy,surgery andcombination have been studied and shared almost comparableresults with survival rate of 70-90%.However,chemotherapypossesses the advantage of preserving gastric anatomy.Radiotherapy alone has been tried and showed good results.Stage IIIE,IVE disease treatment is solely by chemotherapyand surgical resection has been a remote consideration.CONCLUSION:We conclude that methods of diagnosis andstaging of the primary gastric lymphoma have dramaticallyimproved.The modalities of treatment are many and probablychemotherapy is superior because of high success rate,preservation of stomach and tolerable complications.
AIM: The purpose of this review is to describe the various aspects of primary gastric lymphoma and the treatment options currently available. METHODS: After a systematic search of Pubmed, Medscape and MDconsult, we reviewed and retrieved literature on gastrictric lymphoma .RESULTS: Primary gastric lymphoma is rare , theincidence of this malignancy is increasing.Chronic gastritissecondary to Helicobacter pylori (H pylori) infection has beenconsidered a major predisposing factor for MALT lymphoma.Immune histochemical marker studies and molecular biologyutilizing polymerase chain reaction have facilitated appropriatediagnosis and abolished the need for diagnostic surgical procedure. Advances in imaging techniques including Magnetic Resonance Imaging (MRI) and Endoscopic Ultrasonography (EUS) have helped evaluation of tumor extension and invasion. clinical disease and prognosis of this disease is dependenton histopathological sub-type and stage at the time of diagnosis. Confluxy remains regar ding the best treatment for early stages of this disease. Chemotherapy, surgery andcombination have been studied and shared almost comparable with results of survival rate of 70-90%. Despite, chemotherapypossesses the advantage of preserving gastric anatomy. Radiotherapy alone has been tried and showed good results. Stage IIIE, IVE disease treatment is solely by chemotherapy and surgical resection has been a remote consideration. CONCLUSION: We conclude that methods of diagnosis and staging of the primary gastric lymphoma have dramatically impacted. The modalities of treatment are many and probablychemotherapy is superior because of high success rate , preservation of stomach and tolerable complications.