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目的分析胸段食管鳞癌淋巴结转移与临床病理特征的相关性,了解胸段食管鳞癌淋巴结转移的特点。方法 2006年1月~2007年7月在新疆医科大学附属肿瘤医院胸外科收治的215例胸段食管鳞癌患者的手术及临床病理资料,应用Logistic回归方法回顾性分析胸段食管鳞癌淋巴结转移规律及影响因素。结果全组淋巴结总转移率为53.5%(115/215),通过单因素Logistic回归分析:肿瘤部位,肿瘤浸润深度,分化程度与淋巴结转移有关(P<0.05)。性别、族别、体重变化、肿瘤长度、大体病理类型、淋巴管浸润等因素与淋巴结转移无相关性(P>0.05)。通过逐步Logistic回归分析进一步了解上述三个因素与淋巴结转移相关性。结论本研究结果显示:(1)影响淋巴结转移的临床病理因素为肿瘤浸润深度、分化程度、肿瘤位置;(2)胸段食管鳞癌可向颈部、胸部、腹部淋巴引流区域转移,最常见淋巴结转移区域是纵隔,其次为腹部及颈部。
Objective To analyze the correlation between lymph node metastasis and clinicopathological features in thoracic esophageal squamous cell carcinoma and to understand the characteristics of lymph node metastasis in thoracic esophageal squamous cell carcinoma. METHODS: From January 2006 to July 2007, 215 cases of thoracic esophageal squamous cell carcinoma were treated in Department of Thoracic Surgery, Affiliated Tumor Hospital, Xinjiang Medical University. The clinical and pathological data were analyzed retrospectively using Logistic regression to analyze the lymph node metastasis of thoracic esophageal squamous cell carcinoma Rules and influencing factors. Results The total lymph node metastasis rate was 53.5% (115/215). The single factor Logistic regression analysis showed that the tumor location, the depth of tumor invasion and the degree of differentiation were related to lymph node metastasis (P <0.05). Gender, ethnicity, weight change, tumor length, gross pathological type, lymphatic invasion and other factors had no correlation with lymph node metastasis (P> 0.05). By stepwise logistic regression analysis to further understand the above three factors and lymph node metastasis. Conclusions The results of this study showed that: (1) The clinicopathological factors affecting the lymph node metastasis were the depth of tumor invasion, the degree of differentiation and the location of the tumor. (2) Thoracic esophageal squamous cell carcinoma could metastasize to the lymphatic drainage area of the neck, chest and abdomen, Lymph node metastasis area is the mediastinum, followed by the abdomen and neck.