Proteasomal and lysosomal degradation for specific and durable suppression of immunotherapeutic targ

• 作 者: Yungang Wang Shouyan Deng Jie
• 机 构: InstitutesofBiomedicalSciences,DepartmentofLaboratoryMedicine,RenjiHospital
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2020年3期
• 关键词: Cancer immunotherapy membrane protein PROTAC targeted degradation
• 基金项目: This work was supported by the National Natural Science Foundation of China(Grant Nos.81874050,81572326,81322036,81421001,and 81902906),National Key R&D Program of China(Grant No.2016YFC0906002),S

Cancer immunotherapy harness the body's immune system to eliminate cancer,by using a broad panel of soluble and membrane proteins as therapeutic targets.Immunosuppression signaling mediated by ligand-receptor interaction may be blocked by monoclonal a