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目的:观察针刺对2型糖尿病患者胰高血糖素样肽~1(GLP-1)的影响,从而揭示针刺降低2型糖尿病患者血糖的机制。方法:将40例2型糖尿病患者采取随机双盲法分为针刺组和对照组。通过8周的观察,比较2组患者血糖、糖化血红蛋白(Hb Alc)和中医症状积分的变化。结果:2组治疗前各项指标无显著差异;治疗后,针刺组空腹血糖、餐后2h血糖、Hb Alc、0’GLP-1、30’GLP-1较治疗前比较有统计学差异(P<0.05);与对照组比较,空腹血糖、餐后2h血糖、Hb Alc低于对照组,0’GLP-1、30’GLP-1高于对照组,治疗8w时降糖精组症状明显减轻,有统计学差异(P<0.05)。结论:针刺健脾类穴位通过降低2型糖尿病患者的血糖、Hb Alc,提高GLP-1来改善2型糖尿病患者的糖代谢。
Objective: To observe the effect of acupuncture on glucagon-like peptide-1 (GLP-1) in type 2 diabetic patients and to reveal the mechanism of acupuncture in reducing blood glucose in type 2 diabetic patients. Methods: 40 patients with type 2 diabetes were randomly divided into acupuncture group and control group. After 8 weeks of observation, the changes of blood glucose, glycosylated hemoglobin (Hb Alc) and TCM symptom scores in two groups were compared. Results: There was no significant difference between the two groups before treatment. After treatment, fasting blood glucose, postprandial 2h blood glucose, Hb Alc, 0’GLP-1, 30’GLP-1 were significantly different from those before treatment P <0.05). Compared with the control group, fasting blood glucose, postprandial 2h blood glucose and Hb Alc were lower than the control group, and 0’GLP-1 and 30’GLP-1 were higher than those in the control group. Symptoms of hypoglycemic group were obvious at 8w Reduce, there is statistical difference (P <0.05). Conclusion: acupuncture and invigorating the spleen points can improve glucose metabolism in type 2 diabetic patients by decreasing blood glucose, Hb Alc and increasing GLP-1 in type 2 diabetic patients.