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肥胖及其相关疾病改变了毒物代谢动力学特征,诱发机体炎症反应和氧化应激,因而可能改变纳米颗粒物对该人群的健康损伤效应。已有研究发现,糖尿病可加重纳米颗粒物的自主神经、感觉和认知功能的损伤;加快纳米颗粒物引起的血小板聚集,加速血栓、动脉粥样硬化和斑块的形成,增加心血管疾病发病率或者加剧其进程。同时,超重或肥胖及其相关的血脂异常、非酒精性脂肪肝,也加重了纳米颗粒物激发的炎症调节反应以及相应的肺部、肝组织的损伤。因而,在职业和生活环境中接触纳米颗粒物时,应针对纳米颗粒物的理化特性和肥胖相关疾病患者的生理特点,为这一特殊易感人群提供相应的防护措施。
Obesity and its related diseases alter toxicokinetic characteristics, induce inflammation and oxidative stress in the body, and may therefore alter the health effects of nanoparticles on this population. It has been found that diabetes mellitus can aggravate the autonomic nerve, sensory and cognitive impairment of nanoparticles; accelerate the aggregation of platelets by nanoparticles, accelerate the formation of thrombosis, atherosclerosis and plaque, increase the incidence of cardiovascular diseases or Aggravate its progress. At the same time, overweight or obesity and its associated dyslipidemia, non-alcoholic fatty liver, but also aggravate the inflammatory regulation response induced by nanoparticles and the corresponding lung, liver damage. Therefore, exposure to nanoparticles in occupational and living environments should be based on the physical and chemical characteristics of nanoparticles and the physiological characteristics of patients with obesity-related diseases, to provide this special vulnerable groups with appropriate protection measures.