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目的探讨初诊2型糖尿病患者铁负荷的变化。方法初诊2型糖尿病患者30例及健康对照者32例,采用酶联免疫法检测血清铁蛋白(FT)、转铁蛋白(TRF)水平,采用生化法检测空腹血浆葡萄糖、血清铁(Fe)、铁总结合力(TIBC)、血脂水平。结果2型糖尿病血清FT水平显著高于健康对照组(P<0.05),但两组间血清Fe、TIBC、TRF、TRF饱和度(TS)水平差异无显著性(P>0.05)。血清FT与血糖呈显著正相关,与高密度脂蛋白呈显著负相关。结论初诊2型糖尿病患者存在明显铁超载,但铁超载在2型糖尿病发病过程中的作用还有待于进一步研究。
Objective To investigate the changes of iron load in newly diagnosed type 2 diabetic patients. Methods Thirty newly diagnosed type 2 diabetic patients and 32 healthy controls were enrolled in this study. The levels of serum ferritin (FT) and transferrin (TRF) were measured by enzyme-linked immunosorbent assay. Fasting plasma glucose, serum Fe, Iron total combined force (TIBC), blood lipid levels. Results The level of serum FT in type 2 diabetes mellitus group was significantly higher than that in healthy controls (P <0.05). There was no significant difference in serum Fe, TIBC, TRF and TRF saturation between the two groups (P> 0.05). There was a significant positive correlation between serum FT and blood glucose and a significant negative correlation with high density lipoprotein. Conclusions The newly diagnosed patients with type 2 diabetes have obvious iron overload, but the role of iron overload in the pathogenesis of type 2 diabetes remains to be further studied.