论文部分内容阅读
ABCC4、ABCC5是ABCC(ATP-bindingcassette transporter family class C,ABCC)蛋白转运体家族的成员,介导众多内源性代谢产物和外源性药物从细胞内向外转运。ABCC4和ABCC5在体内分布广泛,参与机体对药物和内、外源物质的吸收、分布和排泄等。ABCC4、ABCC5的一些突变会引起转运体表达、功能的改变和机体对药物反应的改变。近年研究发现ABCC4、ABCC5与某些肿瘤的多药耐药相关,转运体的过表达可以引起肿瘤细胞对多种肿瘤化疗药物的耐药性,导致临床化疗效果不佳。本文就转运体ABCC4和ABCC5介导的肿瘤多药耐药研究进展进行综述。
ABCC4 and ABCC5 are members of the ABCC (ATP-binding cassette transporter family class C) protein transporter family and mediate the transport of numerous endogenous metabolites and exogenous drugs from the interior to the exterior of cells. ABCC4 and ABCC5 widely distributed in the body, involved in the body’s absorption of drugs and exogenous substances, distribution and excretion. Some mutations in ABCC4 and ABCC5 cause transporter expression, functional changes, and changes in the body’s response to the drug. Recent studies found that ABCC4 and ABCC5 are associated with multidrug resistance in some tumors. Overexpression of transporter can cause tumor cells to become resistant to various tumor chemotherapeutic drugs, leading to poor clinical chemotherapy. This review summarizes the progress of multidrug resistance tumor-mediated studies of ABCC4 and ABCC5.