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目的探讨大剂量维生素C、维生素E对高原肺心病急性发作期患者脂质过氧化损伤的保护作用。方法选择高原肺心病急性发作期患者126例,分为观察组和对照组,对照组患者应用常规治疗,观察组患者在此基础上应用VitC150～250mg/(kg.d)静脉滴注,VitE100～200mg/d口服,10d为1疗程。结果①观察组患者治疗显效38例,有效22例,无效4例,有效率93.75%。对照组患者治疗显效34例,有效16例,无效12例,有效率80.65%。观察组患者治疗有效率显著高于对照组(P﹤0.05)。②治疗后,两组患者血P-LPO水平均显著降低,P-β-CAR、WB-GSH、E-SOD及E-CAT均显著升高,与治疗前相比差异有统计学意义(P﹤0.05)。治疗后,观察组患者血P-β-CAR、WB-GSH、E-SOD及E-CAT水平均显著高于对照组(P﹤0.05)。结论大剂量维生素C、维生素E对高原肺心病急性发作期患者脂质过氧化损伤具有较好的保护作用。
Objective To investigate the protective effect of high-dose vitamin C and vitamin E on lipid peroxidation in patients with acute pulmonary heart disease at high altitude. Methods A total of 126 patients with acute phase of pulmonary heart disease were randomly divided into observation group and control group. Patients in the control group were treated with routine therapy. Patients in the observation group were treated with VitC 150 ~ 250mg / (kg.d) 200mg / d orally, 10d for a course of treatment. Results ① The observation group of patients treated 38 cases markedly effective in 22 cases, 4 cases were ineffective, the effective rate was 93.75%. The control group of patients treated 34 cases markedly effective in 16 cases, 12 cases were ineffective, the effective rate was 80.65%. The observation group patients treatment efficiency was significantly higher than the control group (P <0.05). ② After treatment, the levels of P-LPO, P-β-CAR, WB-GSH, E-SOD and E-CAT in the two groups were significantly increased compared with those before treatment (P <0.05). After treatment, the levels of P-CAR, WB-GSH, E-SOD and E-CAT in the observation group were significantly higher than those in the control group (P <0.05). Conclusion High-dose vitamin C and vitamin E have a good protective effect on lipid peroxidation injury in acute episode of plateau pulmonary heart disease.