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目的探讨chemerin(趋化因子)在肥胖胆囊结石发生中的作用。方法收集2013年-2014年期间在新疆自治区人民医院住院治疗并确诊的维吾尔族胆囊结石患者的血液标本48例;单纯性肥胖组38例;对照组(经B超诊断无胆石症患者,包括腹股沟疝,切口疝及食道裂孔疝患者)共20例。应用ELISA法检测两组对象血清chemerin的浓度,并进行相关统计分析。结果胆囊结石患者TC,TG,HDL,LDL水平与对照组比较,均无差异(P>0.05)。而血清chemerin水平高于对照组(P<0.05)。结论血清chemerin水平升高可能是肥胖促进胆囊结石的发生的原因。
Objective To investigate the role of chemerin in the development of obesity gallstone. Methods Forty-eight Uygur patients with gallbladder stones admitted to People’s Hospital of Xinjiang Uygur Autonomous Region during 2013-2014 were enrolled in this study. Forty-eight patients in simple obesity group and control group (including patients with achondroplasia diagnosed by B- Hernia, incisional hernia and esophageal hiatal hernia patients) a total of 20 cases. Serum chemerin concentrations in both groups were detected by ELISA, and statistical analysis was performed. Results The levels of TC, TG, HDL and LDL in gallstone patients were not significantly different from those in control group (P> 0.05). Serum chemerin levels were higher than the control group (P <0.05). Conclusions Elevated chemerin level may be the reason of obesity promoting gallstone disease.