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采用免疫组化染色和图像分析技术,检测了9例口腔上皮单纯增生,49例不同程度异常增生和21例鳞状细胞癌中C-erbB-2蛋白产物表达.结果显示.单纯增生中癌基因蛋白无明显异常,轻度异常增生中阳性表达略有增加.随着异常增生程度加重,C-erbB-2阳性细胞明显增多,染色程度显著增强.所有鳞状细胞癌标本均出现C-erbB-2蛋白过量表达.由此提示C-erbB-癌基因与口腔鳞状细胞癌的发生发展过程有关,其蛋白产物检测可作为评估口腔粘膜癌前病变恶变风险的一项有用指标.
The expression of C-erbB-2 protein in 9 cases of oral epithelial hyperplasia, 49 cases of different degree of dysplasia and 21 cases of squamous cell carcinoma were detected by immunohistochemical staining and image analysis.The results showed that the proliferation of oncogene The positive expression of C-erbB-2 positive cells increased slightly and the staining degree increased significantly.With the increasing degree of abnormal proliferation, the expression of C-erbB- 2 protein overexpression, suggesting that C-erbB-oncogene is associated with the development and progression of oral squamous cell carcinoma, and its protein product detection can be used as a useful indicator to evaluate the malignant transformation of oral mucosal precancerous lesions.