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AIM:To review and conduct a meta-analysis of the existing literature on the relationship between Helicobacter pylori(H.pylori),atopy and allergic diseases.METHODS:Studies published in English assessing the prevalence of atopy and/or allergic diseases in patients with H.pylori infection and the prevalence of H.pylori infection in patients with atopy and/or allergic diseases were identified through a MEDLINE search(1950-2014).Random-effect model was used for the meta-analysis.RESULTS:Pooled results of case-control studies showed a significant inverse association of H.pylori infection with atopy/allergic disease or with exclusively atopy,but not with allergic disease,whereas pooled results of cross-sectional studies showed only a significant association between allergic disease and H.pylori infection.CONCLUSION:There is some evidence of an inverse association between atopy/allergic diseases and H.pylori infection,although further studied are needed.
AIM: To review and conduct a meta-analysis of the existing literature on the relationship between Helicobacter pylori (H. pylori), atopy and allergic diseases. METHODS: Studies published in English assessing the prevalence of atopy and / or allergic diseases in patients with H. pylori infection and the prevalence of H. pylori infection in patients with atopy and / or allergic diseases were identified through a MEDLINE search (1950-2014). Random-effect model was used for the meta-analysis .RESULTS: Pooled results of case-control studies showed a significant inverse association of H. pylori infection with atopy / allergic disease or with exclusively atopy, but not with allergic disease, but pooled results of cross-sectional studies showed only a significant association between allergic disease and H. pylori infection.CONCLUSION: There is some evidence of an inverse association between atopy / allergic diseases and H. pylori infection, though further studied are needed.