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为观察性激素对中耳粘膜的作用及雌激素、孕激素受体在正常中耳粘膜的表达，将 ４０ 只大鼠分成 ４ 组，１ 组为对照组，另 ３ 组分别给予雌激素、孕激素、雄激素，以观察其中耳粘膜的变化，并应用免疫组化检测雌激素、孕激素受体在中耳粘膜的表达。结果表明，应用激素组的中耳粘膜与对照组相比未见明显改变，但中耳粘膜雌激素受体阳性。证实中耳粘膜分布有雌激素受体，雌激素可能对中耳粘膜直接起作用。
In order to observe the effect of sex hormones on the middle ear mucosa and the expression of estrogen and progesterone receptors in the normal middle ear mucosa, 40 rats were divided into 4 groups, 1 group was the control group, the other 3 groups were given estrogen, progesterone , Androgen to observe the change of the middle ear mucosa. The expression of estrogen and progesterone receptor in middle ear mucosa was detected by immunohistochemistry. The results showed that the application of hormones in the middle ear mucosa compared with the control group no significant change, but the middle ear mucosa positive for estrogen receptor. Confirmed the distribution of middle ear mucosa estrogen receptor, estrogen may play a direct role in the middle ear mucosa.