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目的观察氧气驱动雾化吸入万托林治疗老年慢性阻塞性肺疾病(COPD)急性加重期并Ⅱ型呼吸衰竭的疗效及安全性。方法将58例老年COPD急性加重期并Ⅱ型呼吸衰竭患者分为治疗组(32例)和对照组(26例),两组均给予吸氧、抗感染、祛痰、解痉、平喘、盐酸氨溴素雾化吸入等综合治疗,治疗组加用万托林雾化吸入,观察两组患者治疗前后症状、体征、动脉血气变化及不良反应。结果治疗组血气指标的改善优于对照组(P<0.05),治疗总有效率高于对照组(P<0.05)。两组不良反应的总发生率比较差异无统计学意义(P>0.05)。结论高流量氧气驱动雾化吸入万托林是治疗老年COPD急性加重期并Ⅱ型呼吸衰竭是有效且安全的方法。
Objective To observe the efficacy and safety of oxygen driven inhalation of wantroplin in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and type Ⅱ respiratory failure. Methods Fifty-eight elderly patients with acute exacerbation of COPD and type Ⅱ respiratory failure were divided into treatment group (32 cases) and control group (26 cases). Both groups were given oxygen, anti-infective, expectorant, antispasmodic, Hydrochloride ammonia bromide inhalation and other comprehensive treatment, the treatment group with Wan Torin atomization inhalation, the two groups were observed before and after treatment of symptoms and signs, arterial blood gas changes and adverse reactions. Results The improvement of blood gas index in the treatment group was better than that in the control group (P <0.05). The total effective rate of treatment was higher than that of the control group (P <0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups (P> 0.05). Conclusion High-flow oxygen-driven inhalation of vaterolin is an effective and safe method for the treatment of senile COPD exacerbation and type Ⅱ respiratory failure.