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目的研究国产ＧｄＤＴＰＡ大剂量（０３ｍｍｏｌ／ｋｇ）静脉注射的安全性、耐受性和效果。方法共研究了４１例患者。分两次注射，第一次注射０１ｍｍｏｌ／ｋｇ，３０分钟后再注射０２ｍｍｏｌ／ｋｇ，从而达到累积０３ｍｍｏｌ／ｋｇ。每次注射后即刻和延时２０分钟时分别行Ｔ１ＷＩ扫描。观察患者检查前后的生命体征，询问患者的主观感觉，２４小时后随访。对于３１例颅内病变患者的６７个病灶还进行了增强效果的分析，计算病灶的相对信噪比：Ｃ／Ｎ＝（病灶信号强度－正常脑白质信号强度）／背景信号强度。结果检查前后患者的生命体征未见明显差异。４例患者报告有副作用，均未经治疗而自行缓解。副作用发生的概率是９７６％。三倍量国产ＧｄＤＴＰＡ的使用可以普遍地提高颅内病灶的相对信噪比。结论使用大剂量（０３ｍｍｏｌ／ｋｇ）国产ＧｄＤＴＰＡ可认为是安全的。对于颅内病变，三倍量增强ＭＲ可提高相对信噪比和病灶的检出率，对于颅内小病变和脑转移瘤尤其有意义。
Objective To study the safety, tolerability and efficacy of high dose GdDTPA (0.3 mmol / kg) intravenous injection. Methods A total of 41 patients were studied. Two injections, the first injection of 0 1mmol / kg, 30 minutes after the injection of 0 2mmol / kg, so as to achieve the cumulative 0 3mmol / kg. T1WI scans were performed immediately after each injection and for a delay of 20 minutes. Observe the patient’s vital signs before and after the examination, ask the patient’s subjective feeling, and follow up after 24 hours. 67 lesions in 31 patients with intracranial lesions were also analyzed for enhancement and the relative signal-to-noise ratio of lesions was calculated: C / N = (signal strength of lesions - normal white matter signal intensity) / background signal intensity. Results Before and after the examination of patients with vital signs no significant difference. Four patients reported side effects, all relieved without treatment. The probability of side effects occurring is 976%. Three times the amount of domestic Gd DTPA can generally improve the relative signal to noise ratio of intracranial lesions. Conclusion The high dose (03mmol / kg) of domestic GdDTPA can be considered as safe. For intracranial lesions, three-fold increase MR can improve the relative signal to noise ratio and the detection rate of lesions, especially for intracranial lesions and brain metastases.