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目的观察黄茯胶囊对尿酸所致大鼠痛风性关节炎模型的影响。方法将雄性SD大鼠60只随机均分为正常组、模型组、吲哚美辛组及黄茯高、中、低剂量组。采用尿酸钠溶液注入大鼠右侧踝关节腔造成急性痛风性关节炎模型,给予正常组生理盐水。观察各组大鼠用药前后一般体征、测量受试关节周径,于末次给药后24 h检测关节周围软组织中PGE2、IL-1、IL-6的含量。结果给药3 d后,黄茯胶囊组大鼠一般体征趋于正常,黄茯高、中剂量组的关节肿胀度较模型组非常显著地降低;黄茯高、中剂量组PGE2含量较模型组显著的降低;黄茯高剂量组的IL-1含量较模型组显著降低;黄茯高、中剂量组的IL-6含量较模型组显著降低。结论黄茯胶囊对痛风性关节炎有抑制关节肿胀和抗炎、镇痛的作用,其作用机制与降低关节周围软组织中炎症因子PGE2、IL-1、IL-6含量有关。
Objective To observe the effect of Huangfu capsule on gouty arthritis model induced by uric acid in rats. Methods Sixty male SD rats were randomly divided into normal group, model group, indomethacin group and Huang Fu high, medium and low dose groups. UA solution injected into the rat right ankle joint cavity caused by acute gouty arthritis model, given normal saline. The general signs of each group were observed before and after treatment, the testicular circumference was measured, and the content of PGE2, IL-1 and IL-6 in the soft tissue around the joint was detected 24 h after the last administration. Results After 3 days of administration, the general signs of the rats in Huangfu Capsule group were normal, and the swelling degree of joint in Huangfu high and middle dose groups was significantly lower than that in model group. The content of PGE2 in Huangfu high and middle dose groups was significantly lower than that in model group. The content of IL-1 in high-dose Huangfu group was significantly lower than that in model group. The content of IL-6 in Huangfu high-dose group was significantly lower than that in model group. Conclusion Huangfu Capsule can inhibit joint swelling and anti-inflammatory and analgesic effects on gouty arthritis, and its mechanism may be related to the reduction of inflammatory factors PGE2, IL-1 and IL-6 in soft tissue around the joint.