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目的 探讨多发性淋巴瘤性息肉病 (MLP)的临床病理特征及诊断要点。方法 对 2例肠道MLP的临床表现 ,病理组织学观察及免疫组化S P法标记进行分析。结果 2例均为 5 0余岁男性 ,因便血作内镜检查 ,巨检发现肠粘膜多处息肉样肿块 ,直径 0 4～ 4cm。组织学瘤细胞为一致性小淋巴细胞与小裂细胞之间的形态 ,围绕滤泡中心生长 ,致使大部分滤泡破坏消失。肿瘤局限于粘膜固有层及粘膜下层 ,不形成淋巴上皮病损。免疫组化 :CD2 0、CD74、CD5阳性 ,单轻链λ表达。结论 MLP是极罕见的胃肠道淋巴瘤 ,属套细胞淋巴瘤 ,看似分化良好 ,却有不良的临床预后
Objective To investigate the clinicopathological features and diagnosis of multiple polyposis of lymphoma (MLP). Methods The clinical manifestations, histopathological observation and immunohistochemical SP method of 2 cases of intestinal MLP were analyzed. Results 2 cases were 50 years old men, because of hematochezia for endoscopy, giant intestinal polyps found in many polyps, diameter 0 4 ~ 4cm. Histology Tumor cells are small morphologically consistent between small lymphocytes and small fission cells that grow around the follicular center, causing most follicular destruction to disappear. Tumor confined to the lamina propria and submucosa, does not form lymphoid lesions. Immunohistochemistry: CD20, CD74, CD5 positive, single light chain lambda expression. Conclusion MLP is a very rare gastrointestinal lymphoma, a mantle cell lymphoma, seemingly well-differentiated, but have a poor clinical prognosis