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目的探讨卵巢霍奇金淋巴瘤的临床病理特征、免疫表型、诊断与鉴别诊断要点。方法对1例卵巢霍奇金淋巴瘤的临床病理资料进行光镜观察及免疫组化检测,并复习相关文献。结果患者女性,31岁。肿瘤位于卵巢。肿瘤切面灰白、灰黄色,局部质地稍嫩。镜下见纤维带包绕肿瘤呈大小不一结节组织,广泛纤维化;部分肿瘤细胞梭形,部分呈上皮样,细胞核大、深染,中~重度异型;内见“爆米花”样大细胞、嗜酸性胞质及致密浓染核的“干尸”样大细胞。肿瘤细胞巢中央见坏死,伴多量中性粒细胞、嗜酸性粒细胞和淋巴细胞浸润。免疫组化显示肿瘤细胞CD15、CD30和Pax5(+)。结论卵巢霍奇金淋巴瘤非常少见,病理组织学检查与卵巢其他恶性肿瘤难鉴别。免疫组化标记检测有助于鉴别诊断。
Objective To investigate the clinical and pathological features, immunophenotype, diagnostic and differential diagnosis of ovary Hodgkin’s lymphoma. Methods One case of ovarian Hodgkin ’s lymphoma was examined by light microscopy and immunohistochemistry. The related literatures were reviewed. Results Female patient, 31 years old. The tumor is located in the ovary. Tumor surface gray, gray, slightly softer local texture. Microscopically see the fiber band around the tumor was the size of a nodular tissue, extensive fibrosis; part of the tumor cell fusiform, part of the epithelium-like, large nucleus, stained, moderate to severe atypia; See “popcorn” Like large cells, eosinophilic cytoplasm and dense stained nuclei “mummy ” like large cells. Necrosis of tumor cells in the middle of the nest, with a large number of neutrophils, eosinophils and lymphocyte infiltration. Immunohistochemistry showed tumor cells CD15, CD30 and Pax5 (+). Conclusions Ovarian Hodgkin’s lymphoma is very rare and histopathological examination is difficult to distinguish from other malignant ovarian tumors. Immunohistochemical detection can be helpful for differential diagnosis.