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本文报道吡喹酮对曼氏血吸虫的虫卵孵化、毛蚴和尾蚴的作用。将感染曼氏血吸虫的小鼠粪便内的虫卵用沉淀法进行分离,并放在有光刺激和27℃的条件下孵出毛蚴,然后将毛蚴和从感染的扁卷螺内逸出的尾蚴培育在含有吡喹酮的药液中。实验在室温条件下进行。实验用雌性 CFI/W74株小鼠,在感染后7天或8周解剖动物,计数童虫和成虫数,与对照组相比较来评价药物的疗效。
This article reports the effect of praziquantel on egg hatching, miracidia and cercariae of Schistosoma mansoni. The eggs in the feces of mice infected with Schistosoma mansoni were separated by precipitation and incubated with miracidia under light stimulation and at 27 ° C. The miracidia and cercariae escaping from the infected flatfish were then hatched Cultivation in praziquantel containing liquid. The experiment was carried out at room temperature. Experimental female CFI / W74 mice were dissected for animals at 7 days or 8 weeks post-infection, and the numbers of schistosomiasis and adult worms were counted. The efficacy of the drug was evaluated in comparison with the control group.